T-Guard™ is a medicine currently under development that safely and swiftly ‘resets’ the body’s immune system. It shows potential in the effective treatment of certain life-threatening immune conditions, such as transplant-related rejection, Graft versus Host Disease (GVHD), acute solid-organ rejection and several severe autoimmune diseases.
After injection into the body, T-Guard destroys mature T- and NK cells, with a strong preference for activated T cells (the trouble makers). T-Guard can do this, because it consists of two anti-T-cell antibodies that act against specific cell membrane-antigens, CD3 and CD7. Each antibody in T-Guard is conjugated to an immunotoxin that prevents the cells from making new proteins, thereby inducing pogrammed cell death (apoptosis).
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The particular combination of immunotoxins used to construct T-Guard provides a unique blend of synergistic efficacy, narrow specificity and multiple gentle mechanisms of action. Its action is unparalleled by any immunosuppressive product currently available commercially.
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When administered in a clinical pilot-study as a one-week course of therapy, T-Guard induced the swift and efficient removal of circulating T cells, followed by impressive biological and clinical responses without causing severe toxicities. Subsequent new T cell development was not accompanied by a recurrence of GVDH. Indicating that T-Guard is capable of ‘resetting’ the immune system.
T-Guard was discovered and developed in the Hematology Department of the Radboud University Nijmegen Medical Center in Nijmegen – One of the Netherlands’ most well-known academic hospitals. It has already proved effective in a clinical pilot study for the treatment of severe acute GVHD.
Xenikos is developing T-Guard for approval as an orphan drug for treating acute Graft versus Host Disease (GVHD) and potentially other indications, in which, hyper-reactive-, misdirected- or malignant T cells are implicated, such as solid organ rejection, autoimmune diseases and T cell derived blood cancers.